Novel Nanoparticles Based on <i>N</i>,<i>O</i>-Carboxymethyl Chitosan-Dopamine Amide Conjugate for Nose-to-Brain Delivery

Novel Nanoparticles Based on <i>N</i>,<i>O</i>-Carboxymethyl Chitosan-Dopamine Amide Conjugate for Nose-to-Brain Delivery

A widely investigated approach to bypass the blood brain barrier is represented by the intranasal delivery of therapeutic agents exploiting the olfactory or trigeminal connections nose-brain. As for Parkinson’s disease (PD), characterized by dopaminergic midbrain neurons degeneration, currently ther...

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Bibliographic Details
Main Authors: Adriana Trapani, Stefania Cometa, Elvira De Giglio, Filomena Corbo, Roberta Cassano, Maria Luisa Di Gioia, Sonia Trombino, Md Niamat Hossain, Sante Di Gioia, Giuseppe Trapani, Massimo Conese
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
dopamine
intranasal administration
polymeric conjugates
polymeric nanoparticles
fluorescent microscopy
Online Access:https://www.mdpi.com/1999-4923/14/1/147

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https://www.mdpi.com/1999-4923/14/1/147

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