Assessment of the protection of dopaminergic neurons by an α7 nicotinic receptor agonist, PHA 543613 using [18F]LBT-999 in a Parkinson’s disease rat model

Assessment of the protection of dopaminergic neurons by an α7 nicotinic receptor agonist, PHA 543613 using [18F]LBT-999 in a Parkinson’s disease rat model

The inverse association between nicotine intake and Parkinson’s Disease (PD) is well established and suggests that this molecule could be neuroprotective through anti-inflammatory action mediated by nicotinic receptors, including the α7-subtype (α7R). The objective of this study was to evaluate the...

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Bibliographic Details
Main Authors: Sophie eSérrière, Aurélie eDoméné, Johnny eVercouillie, Céline eMothes, Sylvie eBodard, Nuno eRodrigues, Denis eGuilloteau, Sylvain eRoutier, Guylène ePage, Sylvie eChalon
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Medicine
Subjects:
Autoradiography
PET
Neuroinflammation
6-hydroxydopamine
TSPO
dopamine transporter
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00061/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00061/full

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