Inhibition of nicotinic acetylcholine receptors by oligoarginine peptides and polyamine-related compounds

Inhibition of nicotinic acetylcholine receptors by oligoarginine peptides and polyamine-related compounds

Oligoarginine peptides, known mostly for their cell-penetrating properties, are also inhibitors of the nicotinic acetylcholine receptors (nAChRs). Since octa-arginine (R8) inhibits α9α10 nAChR and suppresses neuropathic pain, we checked if other polycationic compounds containing amino and/or guanidi...

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Bibliographic Details
Main Authors: Lucy O. Ojomoko, Elena V. Kryukova, Natalya S. Egorova, Arthur I. Salikhov, Lyubov A. Epifanova, Daria A. Denisova, Alex R. Khomutov, Dmitry A. Sukhov, Alexander A. Vassilevski, Maxim A. Khomutov, Victor I. Tsetlin, Irina V. Shelukhina
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Pharmacology
Subjects:
nicotinic acetylcholine receptor
oligoarginine
polyamines
acylpolyamine
radioligand analysis
electrophysiology
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1327603/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1327603/full

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