Multiple Routes to Oestrogen Antagonism

Multiple Routes to Oestrogen Antagonism

Several lines of evidence attest to the existence of alternative ligand binding sites on the oestrogen receptor (ER), including non-competitive inhibition by trilostane or tamoxifen. It is possible that the inhibitory action of conventional oestrogen agonists at high concentrations may indicate that...

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Bibliographic Details
Main Authors: Hilary R. Glover, Stewart Barker, Sylvanie D. M. Malouitre, John R. Puddefoot, Gavin P. Vinson
Format: Article
Language:English
Published: MDPI AG 2010-10-01
Series:Pharmaceuticals
Subjects:
oestrogen receptor
tamoxifen
trilostane
oestradiol
oestrone
oestriol
diethylstilboestrol
amplified in breast cancer
repressor of oestrogenic activity
MCF-7: T47D: LNCaP: PNT1A: ERE
hormesis
allosteric
Online Access:http://www.mdpi.com/1424-8247/3/11/3417/

Internet

http://www.mdpi.com/1424-8247/3/11/3417/

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