Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing.

Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing.

Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively. Altering BIM pre-mRNA splicing is an attractive approach to modulate apoptosis b...

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Bibliographic Details
Main Authors: Wen Chun Juan, Xavier Roca, S Tiong Ong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3990581?pdf=render

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http://europepmc.org/articles/PMC3990581?pdf=render

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