Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects
Abstract CRISPR loss of function screens are powerful tools to interrogate biology but exhibit a number of biases and artifacts that can confound the results. Here, we introduce Chronos, an algorithm for inferring gene knockout fitness effects based on an explicit model of cell proliferation dynamic...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-12-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-021-02540-7 |