Neurosteroids Mediate Neuroprotection in an In Vitro Model of Hypoxic/Hypoglycaemic Excitotoxicity via δ-GABA<sub>A</sub> Receptors without Affecting Synaptic Plasticity

Neurosteroids Mediate Neuroprotection in an In Vitro Model of Hypoxic/Hypoglycaemic Excitotoxicity via δ-GABA<sub>A</sub> Receptors without Affecting Synaptic Plasticity

Neurosteroids and benzodiazepines are modulators of the GABA<sub>A</sub> receptors, thereby causing anxiolysis. Furthermore, benzodiazepines such as midazolam are known to cause adverse side-effects on cognition upon administration. We previously found that midazolam at nanomolar concent...

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Bibliographic Details
Main Authors: Xènia Puig-Bosch, Markus Ballmann, Stefan Bieletzki, Bernd Antkowiak, Uwe Rudolph, Hanns Ulrich Zeilhofer, Gerhard Rammes
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
excitotoxicity
GABA<sub>A</sub> receptors
hippocampus
LTP
neuroprotection
neurosteroids
Online Access:https://www.mdpi.com/1422-0067/24/10/9056

Internet

https://www.mdpi.com/1422-0067/24/10/9056

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