Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study

Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study

Abstract Background Glucokinase (GK) plays a key role in glucose metabolism. In the liver, GK is regulated by GK regulatory protein (GKRP) with nuclear sequestration at low plasma glucose level. Some GK activators (GKAs) disrupt GK-GKRP interaction which increases hepatic cytoplasmic GK level. Exces...

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Bibliographic Details
Main Authors: Ke Wang, Mai Shi, Andrea O. Y. Luk, Alice P. S. Kong, Ronald C. W. Ma, Changhong Li, Li Chen, Elaine Chow, Juliana C. N. Chan
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Cardiovascular Diabetology
Subjects:
Glucokinase
Glucokinase activator
Glucokinase regulatory protein
Mendelian randomization
Triglycerides
Metabolic dysfunction-associated steatotic liver disease
Online Access:https://doi.org/10.1186/s12933-024-02321-z

Internet

https://doi.org/10.1186/s12933-024-02321-z

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