Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis

Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis

Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many neuronal functions that are perturbed in amyotrophic lateral sclerosis (ALS) and perturbation to ER-mitochondria signaling is seen in cell and transgenic models of ALS. However, there is currently little evidence that E...

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Bibliographic Details
Main Authors: Naomi Hartopp, Dawn H W. Lau, Sandra M. Martin-Guerrero, Andrea Markovinovic, Gábor M. Mórotz, Jenny Greig, Elizabeth B. Glennon, Claire Troakes, Patricia Gomez-Suaga, Wendy Noble, Christopher C.J. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
VAPB
PTPIP51
endoplasmic reticulum
mitochondria
amyotrophic lateral sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.950767/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.950767/full

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