Pulmonary Iron Limitation Induced by Exogenous Type I IFN Protects Mice from <named-content content-type="genus-species">Cryptococcus gattii</named-content> Independently of T Cells

Pulmonary Iron Limitation Induced by Exogenous Type I IFN Protects Mice from <named-content content-type="genus-species">Cryptococcus gattii</named-content> Independently of T Cells

ABSTRACT Cryptococcus neoformans causes deadly mycosis primarily in AIDS patients, whereas Cryptococcus gattii infects mostly non-HIV patients, even in regions with high burdens of HIV/AIDS and an established environmental presence of C. gattii. As HIV induces type I IFN (t1IFN), we hypothesized tha...

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Bibliographic Details
Main Authors: Michael J. Davis, Shannon Moyer, Elizabeth S. Hoke, Edward Sionov, Katrin D. Mayer-Barber, Dan L. Barber, Hongyi Cai, Lisa Jenkins, Peter J. Walter, Yun C. Chang, Kyung J. Kwon-Chung
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
Cryptococcus gattii
Cryptococcus neoformans
HIV
MDA-5
interferons
iron
Online Access:https://journals.asm.org/doi/10.1128/mBio.00799-19

Internet

https://journals.asm.org/doi/10.1128/mBio.00799-19

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