Bridging the translational gap: what can synaptopathies tell us about autism?

Bridging the translational gap: what can synaptopathies tell us about autism?

Multiple molecular pathways and cellular processes have been implicated in the neurobiology of autism and other neurodevelopmental conditions. There is a current focus on synaptic gene conditions, or synaptopathies, which refer to clinical conditions associated with rare genetic variants disrupting...

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Bibliographic Details
Main Authors: Ciara J. Molloy, Jennifer Cooke, Nicholas J. F. Gatford, Alejandro Rivera-Olvera, Sahar Avazzadeh, Judith R. Homberg, Joanes Grandjean, Cathy Fernandes, Sanbing Shen, Eva Loth, Deepak P. Srivastava, Louise Gallagher
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism
NRXN1 deletion
Phelan-McDermid syndrome
SHANK3
synaptopathy
preclinical models
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1191323/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1191323/full

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