Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury

Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury

The neurochemical mechanisms underlying neuropathic pain (NP) are related to peripheral and central sensitization caused by the release of inflammatory mediators in the peripheral damaged tissue and ectopic discharges from the injured nerve, leading to a hyperexcitable state of spinal dorsal horn ne...

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Bibliographic Details
Main Authors: P. Medeiros, I.R. dos Santos, A.C. Medeiros, J.A. da Silva, S.H. Ferreira, R.L. de Freitas, N.C. Coimbra
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2020-04-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Non-steroidal anti-inflammatory drugs
Indomethacin
Chronic constriction injury of the nervus ischiadicus
Neuropathic pain
Mechanical allodynia
von Frey test
Online Access:http://www.scielo.br/pdf/bjmbr/v53n5/1414-431X-bjmbr-53-5-e9255.pdf

Internet

http://www.scielo.br/pdf/bjmbr/v53n5/1414-431X-bjmbr-53-5-e9255.pdf

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