Stat3 role in the protective effect of FXR agonists in parenteral nutrition-associated cholestasis

Stat3 role in the protective effect of FXR agonists in parenteral nutrition-associated cholestasis

Background and Aims:. Parenteral nutrition (PN) in patients with intestinal failure can lead to cholestasis (PNAC). In a PNAC mouse model, farnesoid X receptor (FXR) agonist (GW4064) treatment alleviated IL-1β-dependent cholestatic liver injury. The objective of this study was to determine whether t...

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Bibliographic Details
Main Authors: Swati Ghosh, Michael W. Devereaux, Aimee L. Anderson, *Karim C. El Kasmi, Ronald J. Sokol
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2023-03-01
Series:Hepatology Communications
Online Access:http://journals.lww.com/10.1097/HC9.0000000000000056

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http://journals.lww.com/10.1097/HC9.0000000000000056

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