A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis

A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis

The kinase interaction motif protein tyrosine phosphatases (KIM-PTPs), HePTP, PTPSL and STEP, are involved in the negative regulation of mitogen-activated protein kinase (MAPK) signalling pathways and are important therapeutic targets for a number of diseases. We have used VSpipe, a virtual screenin...

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Bibliographic Details
Main Authors: James Adams, Benjamin P. Thornton, Lydia Tabernero
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
protein phosphatases (PPases)
phosphatase inhibitors
hematopoietic protein tyrosine phosphatase (HePTP)
striatum-enriched protein tyrosine phosphatase (STEP)
protein tyrosine phosphatase SL (PTP-SL)
kinase interaction motif protein tyrosine phosphatases (KIM-PTPs)
Online Access:https://www.mdpi.com/1422-0067/22/22/12206

Internet

https://www.mdpi.com/1422-0067/22/22/12206

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