Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells

Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells

The activation mechanism of class B G-protein-coupled receptors (GPCRs) remains largely unknown. To characterize conformational changes induced by peptide hormones, we investigated interactions of the class B corticotropin-releasing factor receptor type 1 (CRF1R) with two peptide agonists and three...

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Bibliographic Details
Main Authors: Lisa Seidel, Barbara Zarzycka, Saheem A Zaidi, Vsevolod Katritch, Irene Coin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
class B GPCRs
expanded genetic code
bioorthogonal crosslinking
molecular modeling
orthosteric antagonism
peptide ligands
Online Access:https://elifesciences.org/articles/27711

Internet

https://elifesciences.org/articles/27711

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