Genome‐wide off‐target analyses of CRISPR/Cas9‐mediated T‐cell receptor engineering in primary human T cells

Genome‐wide off‐target analyses of CRISPR/Cas9‐mediated T‐cell receptor engineering in primary human T cells

Abstract Objectives Exploiting the forces of human T cells for treatment has led to the current paradigm of emerging immunotherapy strategies. Genetic engineering of the T‐cell receptor (TCR) redirects specificity, ablates alloreactivity and brings significant progress and off‐the‐shelf options to e...

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Bibliographic Details
Main Authors: Theresa Kaeuferle, Tanja A Stief, Stefan Canzar, Nayad N Kutlu, Semjon Willier, Dana Stenger, Paulina Ferrada‐Ernst, Nicola Habjan, Annika E Peters, Dirk H Busch, Tobias Feuchtinger
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical & Translational Immunology
Subjects:
CRISPR/Cas9
genetic engineering
off‐target
T‐cell receptor
T‐cell therapy
whole‐genome sequencing
Online Access:https://doi.org/10.1002/cti2.1372

Internet

https://doi.org/10.1002/cti2.1372

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