Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis

Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis

The tumor-intrinsic NOD-like receptor family, pyrin-domain-containing-3 (NLRP3) inflammasome, plays an important role in regulating immunosuppressive myeloid cell populations in the tumor microenvironment (TME). While prior studies have described the activation of this inflammasome in driving pro-tu...

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Bibliographic Details
Main Authors: Balamayooran Theivanthiran, Tarek Haykal, Linda Cao, Alisha Holtzhausen, Michael Plebanek, Nicholas C. DeVito, Brent A. Hanks
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
NLRP3 inflammasome
HSP70
adaptive immunotherapy resistance
granulocytic myeloid-derived suppressor cells
Online Access:https://www.mdpi.com/2072-6694/13/19/4753

Internet

https://www.mdpi.com/2072-6694/13/19/4753

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