Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent

Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Songet al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter ENT1 resulting from coordinated adenosine generatio...

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Bibliographic Details
Main Authors: Anren Song, Yujin Zhang, Leng Han, Gennady G. Yegutkin, Hong Liu, Kaiqi Sun, Angelo D’Alessandro, Jessica Li, Harry Karmouty-Quintana, Takayuki Iriyama, Tingting Weng, Shushan Zhao, Wei Wang, Hongyu Wu, Travis Nemkov, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Kirk C. Hansen, Hong Zhang, Mikhail Bogdanov, William Dowhan, Jianping Jin, Rodney E. Kellems, Holger K. Eltzschig, Michael Blackburn, Robert C. Roach, Yang Xia
Format: Article
Language:English
Published: Nature Portfolio 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14108

Internet

https://doi.org/10.1038/ncomms14108

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