CD4+CD69+ T cells and CD4+CD25+FoxP3+ Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice

CD4+CD69+ T cells and CD4+CD25+FoxP3+ Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice

Abstract Background Adaptive immune cells, including CD4+CD69+ and CD4+CD25+FoxP3+ regulatory T (Treg) cells, are important for maintaining immunological tolerance. In human systemic lupus erythematosus (SLE), CD4+CD25+FoxP3+ Treg cells are reduced, whereas CD69 expression is increased, resulting in...

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Bibliographic Details
Main Authors: Tatiana Vasconcelos Peixoto, Solange Carrasco, Domingos Alexandre Ciccone Botte, Sergio Catanozi, Edwin Roger Parra, Thaís Martins Lima, Natasha Ugriumov, Francisco Garcia Soriano, Suzana Beatriz Verissímo de Mello, Caio Manzano Rodrigues, Cláudia Goldenstein-Schainberg
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Advances in Rheumatology
Online Access:http://link.springer.com/article/10.1186/s42358-019-0072-x

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http://link.springer.com/article/10.1186/s42358-019-0072-x

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