Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease

Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease

Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of the earliest events in Alzheimer’s disease (AD) and is thought to be the major cause of the cognitive deficits. These abnormalities rely on defects in synaptic plasticity, a series of events manifested as ac...

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Bibliographic Details
Main Authors: Carolina Flores-Muñoz, Bárbara Gómez, Elena Mery, Paula Mujica, Ivana Gajardo, Claudio Córdova, Daniela Lopez-Espíndola, Claudia Durán-Aniotz, Claudio Hetz, Pablo Muñoz, Arlek M. Gonzalez-Jamett, Álvaro O. Ardiles
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
pannexin 1
Alzheimer’s disease
amyloid-β peptide
synaptic plasticity
p38 mitogen-activated protein kinase (MAPK)
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00046/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00046/full

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