Single-molecule imaging reveals distinct elongation and frameshifting dynamics between frames of expanded RNA repeats in C9ORF72-ALS/FTD

Single-molecule imaging reveals distinct elongation and frameshifting dynamics between frames of expanded RNA repeats in C9ORF72-ALS/FTD

Abstract C9ORF72 hexanucleotide repeat expansion is the most common genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). One pathogenic mechanism is the accumulation of toxic dipeptide repeat (DPR) proteins like poly-GA, GP and GR, produced by the noncanonical...

Full description

Bibliographic Details
Main Authors: Malgorzata J. Latallo, Shaopeng Wang, Daoyuan Dong, Blake Nelson, Nathan M. Livingston, Rong Wu, Ning Zhao, Timothy J. Stasevich, Michael C. Bassik, Shuying Sun, Bin Wu
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41339-x

Internet

https://doi.org/10.1038/s41467-023-41339-x

Similar Items