Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol

Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol

Astrocytes represent the most abundant cell type in the brain, where they play critical roles in synaptic transmission, cognition, and behavior. Recent discoveries show astrocytes are involved in synaptic dysfunction during Alzheimer’s disease (AD). AD patients have imbalanced cholesterol metabolism...

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Bibliographic Details
Main Authors: Fokion Spanos, Gorka Gerenu, Julen Goikolea, María Latorre-Leal, Hugo Balleza-Tapia, Karen Gomez, Laura Álvarez-Jiménez, Antonio Piras, Marta Gómez-Galán, André Fisahn, Angel Cedazo-Minguez, Silvia Maioli, Raúl Loera-Valencia
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
astrocytes
Alzheimer’s disease
cholesterol metabolism
27-hydroxycholesterol
3D co-culture system
synaptic dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1347535/full

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https://www.frontiersin.org/articles/10.3389/fncel.2024.1347535/full

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