IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson’s disease models

IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson’s disease models

Abstract Parkinson’s disease (PD) is the second most common late-onset neurodegenerative disease and the predominant cause of movement problems. PD is characterized by motor control impairment by extensive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). This selective dopa...

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Bibliographic Details
Main Authors: Javiera Arcos, Felipe Grunenwald, Denisse Sepulveda, Carolina Jerez, Valentina Urbina, Tomas Huerta, Paulina Troncoso-Escudero, Daniel Tirado, Angela Perez, Rodrigo Diaz-Espinoza, Esteban Nova, Ulrich Kubitscheck, Juan Eduardo Rodriguez-Gatica, Claudio Hetz, Jorge Toledo, Pablo Ahumada, Diego Rojas-Rivera, Elisa Martín-Montañez, María Garcia-Fernandez, René L. Vidal
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01734-1

Internet

https://doi.org/10.1038/s41420-023-01734-1

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