ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy

ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy

Abstract Background Glycolysis under normoxic conditions, known as the Warburg effect, confers a selective advantage for the survival and proliferation of many tumors. In this study, we investigated the role of estrogen-related receptor gamma (ESRRG) in metabolic reprogramming in esophageal squamous...

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Bibliographic Details
Main Authors: Tianxiao Wang, Yongjun Zhu, Lu Chen, WenXin Zhang, Huijie Qi, Xiaojin Shi, Mingkang Zhong, Haifei Chen, Qunyi Li
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Translational Medicine
Subjects:
Estrogen-related receptor gamma
Pyruvate kinase M2
Esophageal squamous cell carcinoma
Glycolysis
Online Access:https://doi.org/10.1186/s12967-023-04347-5

Internet

https://doi.org/10.1186/s12967-023-04347-5

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