Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay

Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay

Background and aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells through the binding of the viral spike protein with human angiotensin-converting enzyme 2 (ACE2), resulting in the development of coronavirus disease 2019 (COVID-19). To date, few antiviral drugs are availa...

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Bibliographic Details
Main Authors: Guan-Yu Chen, Yi-Cheng Pan, Tung-Ying Wu, Tsung-You Yao, Wei-Jan Wang, Wan-Jou Shen, Azaj Ahmed, Shu-Ting Chan, Chih-Hsin Tang, Wei-Chien Huang, Mien-Chie Hung, Juan-Cheng Yang, Yang-Chang Wu
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Journal of Traditional and Complementary Medicine
Subjects:
SARS-CoV-2
Spike protein
Virtual screening
Isothermal titration calorimetry
Lentivirus particles pseudotyped (Vpp) infection assay
Online Access:http://www.sciencedirect.com/science/article/pii/S2225411021001188

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http://www.sciencedirect.com/science/article/pii/S2225411021001188

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