The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features

The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features

Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confounding variables of age and sex, 7α,(25R)26-dihydrox...

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Bibliographic Details
Main Authors: William J. Griffiths, Jonas Abdel-Khalik, Sarah F. Moore, Ruwani S. Wijeyekoon, Peter J. Crick, Eylan Yutuc, Krista Farrell, David P. Breen, Caroline H. Williams-Gray, Spyridon Theofilopoulos, Ernest Arenas, Miles Trupp, Roger A. Barker, Yuqin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
sterol
oxysterol
dihydroxycholesterol
bile acid biosynthesis
mass spectrometry
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.685594/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.685594/full

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