Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors

Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors

Phosphoglycerate mutase 1 (PGAM1) coordinates glycolysis and biosynthesis to promote cancer cell proliferation, and is believed to be a promising target for cancer therapy. Herein, based on the anthraquinone scaffold, we synthesized 31 anthraquinone derivatives and investigated the structure&#87...

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Bibliographic Details
Main Authors: Ke Huang, Lulu Jiang, Huiti Li, Deyong Ye, Lu Zhou
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
phosphoglycerate mutase 1
anthraquinone inhibitors
co-crystal structure
cancer treatment
Online Access:https://www.mdpi.com/1420-3049/24/5/845

Internet

https://www.mdpi.com/1420-3049/24/5/845

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