Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities

Abstract There have been an increasing number of patients with degenerative disc diseases due to the aging population. In light of this, studies on the pathogenesis of intervertebral disc degeneration have become a hot topic, and gene knockout mice have become a valuable tool in this field of resear...

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Bibliographic Details
Main Authors: Ze‐Yu Lu, Peng‐Bo Chen, Qing‐Yin Xu, Bo Li, Sheng‐Dan Jiang, Lei‐Sheng Jiang, Xin‐Feng Zheng
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:JOR Spine
Subjects:
Online Access:https://doi.org/10.1002/jsp2.1242