New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1′-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT<sub>1A</sub>/5-HT<sub>7</sub> Affinity and Its Antidepressant-like Activity

New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1′-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT<sub>1A</sub>/5-HT<sub>7</sub> Affinity and Its Antidepressant-like Activity

Serotonin 5-HT<sub>1A</sub> and 5-HT<sub>7</sub> receptors play an important role in the pathogenesis and pharmacotherapy of depression. Previously identified <i>N</i>-hexyl trazodone derivatives, 2-(6-(4-(3-chlorophenyl)piperazin-1-yl)hexyl)-[1,2,4]triazolo[4,3-&...

Full description

Bibliographic Details
Main Authors: Przemysław Zaręba, Anna Partyka, Gniewomir Latacz, Grzegorz Satała, Paweł Zajdel, Jolanta Jaśkowska
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
microwave
reductive alkylation
antidepressant
serotonin
arylpiperazine
Online Access:https://www.mdpi.com/1420-3049/27/21/7270

Internet

https://www.mdpi.com/1420-3049/27/21/7270

Similar Items