Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8+ T cell responses against an arthritogenic alphavirus

Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8+ T cell responses against an arthritogenic alphavirus

ABSTRACT Ross River virus (RRV) and other alphaviruses cause chronic musculoskeletal syndromes that are associated with viral persistence, which suggests deficits in immune clearance mechanisms, including CD8+ T-cell responses. Here, we used a recombinant RRV-gp33 that expresses the immunodominant C...

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Bibliographic Details
Main Authors: Christopher B. Bullock, Leran Wang, Brian C. Ware, Ngan Wagoner, Ray A. Ohara, Tian-Tian Liu, Pritesh Desai, Bjoern Peters, Kenneth M. Murphy, Scott A. Handley, Thomas E. Morrison, Michael S. Diamond
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:mBio
Subjects:
alphavirus
viral pathogenesis
interferons
T cells
T-cell immunity
Online Access:https://journals.asm.org/doi/10.1128/mbio.02930-24

Internet

https://journals.asm.org/doi/10.1128/mbio.02930-24

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