A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia

The genetic mechanisms regulating the brain and behaviour across the lifespan are poorly understood. We found that lifespan transcriptome trajectories describe a calendar of gene regulatory events in the brain of humans and mice. Transcriptome trajectories defined a sequence of gene expression chang...

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Bibliographic Details
Main Authors: Nathan G Skene, Marcia Roy, Seth GN Grant
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/17915