Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in <i>MSH2+/-</i> Carriers
Lynch syndrome (LS) is an inherited predisposition to early onset of various cancers, caused by mutation in a DNA mismatch repair (MMR) gene. In heterozygous MMR<sup>+/−</sup> carriers, somatic mutation, loss or silencing of the wild type allele increases the mutation rate, facilitating...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
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| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/10/11/265 |