Cancer-associated TERT promoter mutations abrogate telomerase silencing

Cancer-associated TERT promoter mutations abrogate telomerase silencing

Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established. We used genome editing of human pluripotent stem cells with physiological telomerase expression to el...

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Bibliographic Details
Main Authors: Kunitoshi Chiba, Joshua Z Johnson, Jacob M Vogan, Tina Wagner, John M Boyle, Dirk Hockemeyer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
telomerase TERT
immortalization
cancer mechanism
genome editing
tumor spectrum
CRISPR/CRISPR-associated systems 9 CAS9
Online Access:https://elifesciences.org/articles/07918

Internet

https://elifesciences.org/articles/07918

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