Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya

Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya

Artemether–lumefantrine (AL) became the first-line treatment for uncomplicated malaria in Kenya in 2006. Studies have shown AL selects for SNPs in pfcrt and pfmdr1 genes in recurring parasites compared to the baseline infections. The genotypes associated with AL selection are K76 in pfcrt and N86, 1...

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Bibliographic Details
Main Authors: Angela O. Achieng, Peninah Muiruri, Luicer A. Ingasia, Benjamin H. Opot, Dennis W. Juma, Redemptah Yeda, Bidii S. Ngalah, Bernhards R. Ogutu, Ben Andagalu, Hoseah M. Akala, Edwin Kamau
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Artemether–lumefantrine
Drug-resistance
Western Kenya
Artemisinin-based combination therapies
Africa
Chloroquine
Molecular markers
Genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320715300014

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http://www.sciencedirect.com/science/article/pii/S2211320715300014

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