Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight

Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight

Abstract Background Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of the human disease. However, behavioural phenotypes are often subtle and p...

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Bibliographic Details
Main Authors: Ellen T. Koch, Judy Cheng, Daniel Ramandi, Marja D. Sepers, Alex Hsu, Tony Fong, Timothy H. Murphy, Eric Yttri, Lynn A. Raymond
Format: Article
Language:English
Published: BMC 2024-05-01
Series:BMC Biology
Subjects:
Neuroscience
Behaviour
Huntington disease
Rotarod
Open field
T-maze
Online Access:https://doi.org/10.1186/s12915-024-01919-9

Internet

https://doi.org/10.1186/s12915-024-01919-9

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