Properties of Parallel Tetramolecular G-Quadruplex Carrying <i>N</i>-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes

Properties of Parallel Tetramolecular G-Quadruplex Carrying <i>N</i>-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes

The development of oligonucleotide conjugates for in vivo targeting is one of the most exciting areas for oligonucleotide therapeutics. A major breakthrough in this field was the development of multifunctional GalNAc-oligonucleotides with high affinity to asialoglycoprotein receptors (ASGPR) that di...

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Bibliographic Details
Main Authors: Anna Clua, Santiago Grijalvo, Namrata Erande, Swati Gupta, Kristina Yucius, Raimundo Gargallo, Stefania Mazzini, Muthiah Manoharan, Ramon Eritja
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
G-quadruplex
<i>N</i>-acetylgalactosamine
antisense
oligonucleotide conjugates
asialoglycoprotein receptor
luciferase gene
Online Access:https://www.mdpi.com/1420-3049/27/12/3944

Internet

https://www.mdpi.com/1420-3049/27/12/3944

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