O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

Background Protein posttranslational modifications by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) increase with cardiac hypertrophy, yet the functional effects of these changes are incompletely understood. In other organs, O‐GlcNAc promotes adaptation to acute physiological stressors; however, prolong...

תיאור מלא

מידע ביבליוגרפי
Main Authors: Wei‐Zhong Zhu, Danny El‐Nachef, Xiulan Yang, Dolena Ledee, Aaron K. Olson
פורמט: Article
שפה:English
יצא לאור: Wiley 2019-06-01
סדרה:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
נושאים:
cardiac failure
cardiac hypertrophy
O‐GlcNAc
OGT
pressure overload
protein kinase A phosphorylation
גישה מקוונת:https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

אינטרנט

https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

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