O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

Background Protein posttranslational modifications by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) increase with cardiac hypertrophy, yet the functional effects of these changes are incompletely understood. In other organs, O‐GlcNAc promotes adaptation to acute physiological stressors; however, prolong...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Wei‐Zhong Zhu, Danny El‐Nachef, Xiulan Yang, Dolena Ledee, Aaron K. Olson
التنسيق: مقال
اللغة:English
منشور في: Wiley 2019-06-01
سلاسل:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
الموضوعات:
cardiac failure
cardiac hypertrophy
O‐GlcNAc
OGT
pressure overload
protein kinase A phosphorylation
الوصول للمادة أونلاين:https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

الانترنت

https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

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