O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

Background Protein posttranslational modifications by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) increase with cardiac hypertrophy, yet the functional effects of these changes are incompletely understood. In other organs, O‐GlcNAc promotes adaptation to acute physiological stressors; however, prolong...

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Dettagli Bibliografici
Autori principali: Wei‐Zhong Zhu, Danny El‐Nachef, Xiulan Yang, Dolena Ledee, Aaron K. Olson
Natura: Articolo
Lingua:English
Pubblicazione: Wiley 2019-06-01
Serie:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Soggetti:
cardiac failure
cardiac hypertrophy
O‐GlcNAc
OGT
pressure overload
protein kinase A phosphorylation
Accesso online:https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

Accesso online

https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

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