O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

Background Protein posttranslational modifications by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) increase with cardiac hypertrophy, yet the functional effects of these changes are incompletely understood. In other organs, O‐GlcNAc promotes adaptation to acute physiological stressors; however, prolong...

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Detalhes bibliográficos
Principais autores: Wei‐Zhong Zhu, Danny El‐Nachef, Xiulan Yang, Dolena Ledee, Aaron K. Olson
Formato: Artigo
Idioma:English
Publicado em: Wiley 2019-06-01
coleção:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:
cardiac failure
cardiac hypertrophy
O‐GlcNAc
OGT
pressure overload
protein kinase A phosphorylation
Acesso em linha:https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

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