O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

Background Protein posttranslational modifications by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) increase with cardiac hypertrophy, yet the functional effects of these changes are incompletely understood. In other organs, O‐GlcNAc promotes adaptation to acute physiological stressors; however, prolong...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Wei‐Zhong Zhu, Danny El‐Nachef, Xiulan Yang, Dolena Ledee, Aaron K. Olson
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Wiley 2019-06-01
Ráidu:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Fáttát:
cardiac failure
cardiac hypertrophy
O‐GlcNAc
OGT
pressure overload
protein kinase A phosphorylation
Liŋkkat:https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

Interneahtta

https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

Geahča maid