Characterising seizure development, behavioural comorbidities and neuroinflammation in a self-sustained electrical status epilepticus model of mesial temporal lobe epilepsy in C57BL/6J mice

Characterising seizure development, behavioural comorbidities and neuroinflammation in a self-sustained electrical status epilepticus model of mesial temporal lobe epilepsy in C57BL/6J mice

Objective: Status epilepticus (SE) models in rodents are commonly used to research mesial temporal lobe epilepsy (mTLE) in translational epilepsy research. However, due to differences in susceptibility of mice strains to chemoconvulsants, developing this model in mice is challenging. Mice offer expe...

Full description

Bibliographic Details
Main Authors: Peravina Thergarajan, Matthew R. Hudson, Irena Carmichael, Jérôme Clasadonte, Stefanie Dedeurwaerdere, Terence J. O'Brien, Nigel C. Jones, Idrish Ali
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Neurobiology of Disease
Subjects:
Electrical stimulation
Animal model
Neuroinflammation
Behaviour
Mesial temporal lobe epilepsy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122000791

Internet

http://www.sciencedirect.com/science/article/pii/S0969996122000791

Similar Items