2045 The role of TGFβ in driving early cystic fibrosis lung disease

2045 The role of TGFβ in driving early cystic fibrosis lung disease

OBJECTIVES/SPECIFIC AIMS: Transforming growth factor-beta (TGFβ) is a genetic modifier of cystic fibrosis (CF) lung disease. TGFβ’s pulmonary levels in young CF patients and its mechanism of action in CF are unknown. We examined TGFβ levels in children with CF and investigated responses of human air...

Full description

Bibliographic Details
Main Authors:	Elizabeth L. Kramer, William Hardie, Kristin Hudock, Cynthia Davidson, Alicia Ostmann, John P. Clancy
Format:	Article
Language:	English
Published:	Cambridge University Press 2018-06-01
Series:	Journal of Clinical and Translational Science
Online Access:	https://www.cambridge.org/core/product/identifier/S2059866118001395/type/journal_article

Similar Items

CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity
by: Elizabeth L. Kramer, et al.
Published: (2023-08-01)

3123 TGFbeta, Early Cytokine Dysregulation, and Airway Smooth Muscle Dysfunction in Cystic Fibrosis
by: Elizabeth L Kramer, et al.
Published: (2019-03-01)

Tgf-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia.
by: Hongtao Sun, et al.
Published: (2014-01-01)

Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease.
by: William T Harris, et al.
Published: (2013-01-01)

The effect of TGF-β1 polymorphisms on pulmonary disease progression in patients with cystic fibrosis
by: T. Trojan, et al.
Published: (2022-05-01)

'Seniors will double by 2045'
by: Sri Priya, Sheila
Published: (2020)

Indonesia Gold 2045
by: Dedy Surahman, et al.
Published: (2021-11-01)

Correction: Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease
Published: (2013-01-01)

Inhibition of TGFβ1 activation prevents radiation‐induced lung fibrosis
by: Minxiao Yi, et al.
Published: (2024-01-01)

Lung Microbiome in Cystic Fibrosis
by: Filippo Scialo, et al.
Published: (2021-01-01)

Fibrosis in PCLS: comparing TGF-β and fibrotic cocktail
by: Carlos Machahua, et al.
Published: (2025-01-01)

TGF-β Inhibitors for Therapeutic Management of Kidney Fibrosis
by: Cheol Ho Park, et al.
Published: (2022-11-01)

PARADIGMA MEMBANGUN GENERASI EMAS INDONESIA TAHUN 2045
by: Antonius Remigius Abi
Published: (2017-12-01)

Advances on TGF-β/Smad signal pathway in hepatic fibrosis
by: Han Daoning, et al.
Published: (2021-09-01)

The Synergistic Cooperation between TGF-β and Hypoxia in Cancer and Fibrosis
by: Pramod Mallikarjuna, et al.
Published: (2022-04-01)

Optimal control of TGF-β to prevent formation of pulmonary fibrosis.
by: Fateme Bahram Yazdroudi, et al.
Published: (2022-01-01)

Targeting TGF-β signal transduction for fibrosis and cancer therapy
by: Dandan Peng, et al.
Published: (2022-04-01)

Lumican promotes joint fibrosis through TGF‐β signaling
by: Dahai Xiao, et al.
Published: (2020-11-01)

Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge
by: Bram ePiersma, et al.
Published: (2015-09-01)

Innate immunity in cystic fibrosis lung disease.
by: Hartl, D, et al.
Published: (2012)

PECULIARITIES OF RADIATION DIAGNOSTIC OF LUNGS WITH CYSTIC FIBROSIS
by: Artem Malysh, et al.
Published: (2019-06-01)

Lung function and microbiota diversity in cystic fibrosis
by: Leah Cuthbertson, et al.
Published: (2020-04-01)

Regulation of the Inflammasome by Ceramide in Cystic Fibrosis Lungs
by: Heike Grassmé, et al.
Published: (2014-06-01)

Bacterial activity in cystic fibrosis lung infections
by: Hockey Peter M, et al.
Published: (2005-06-01)

Cystic Fibrosis Lung Disease in the Aging Population
by: Lisa Künzi, et al.
Published: (2021-04-01)

Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes
by: Ruchi Yadav, et al.
Published: (2023-09-01)

Transforming Growth Factor β1 Genotypes in Relation to TGFβ1, Interleukin-8, and Tumor Necrosis Factor Alpha in Induced Sputum and Blood in Cystic Fibrosis
by: O. Eickmeier, et al.
Published: (2013-01-01)

ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts
by: Ruyan Wan, et al.
Published: (2023-11-01)

HSPB5 Inhibition by NCI-41356 Reduces Experimental Lung Fibrosis by Blocking TGF-β1 Signaling
by: Julie Tanguy, et al.
Published: (2023-01-01)

Time and phenotype-dependent transcriptome analysis in AAV-TGFβ1 and Bleomycin-induced lung fibrosis models
by: Benjamin Strobel, et al.
Published: (2022-07-01)

Multivariate joint modeling to identify markers of growth and lung function decline that predict cystic fibrosis pulmonary exacerbation onset
by: E. R. Andrinopoulou, et al.
Published: (2020-05-01)

Islamic Education Management in Preparing the Demographic Bonus in Indonesia in 2045
by: Sedya Santosa, et al.
Published: (2022-01-01)

Kebijakan olahraga nasional menuju Indonesia Emas tahun 2045
by: Zainal Amali
Published: (2022-09-01)

Targeting TGFβ Signaling to Address Fibrosis Using Antisense Oligonucleotides
by: James T. March, et al.
Published: (2018-06-01)

Flexible semiparametric joint modeling: an application to estimate individual lung function decline and risk of pulmonary exacerbations in cystic fibrosis
by: Dan Li, et al.
Published: (2017-11-01)

Organ Fibrosis and Autoimmunity: The Role of Inflammation in TGFβ-Dependent EMT
by: Margherita Sisto, et al.
Published: (2021-02-01)

The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
by: Francesco Dituri, et al.
Published: (2019-09-01)

Del-1, an Endogenous Inhibitor of TGF-β Activation, Attenuates Fibrosis
by: Dong-Young Kim, et al.
Published: (2020-02-01)

Bacteriocin-mediated competition in cystic fibrosis lung infections.
by: Ghoul, M, et al.
Published: (2015)

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung
by: Matthew S. Twigg, et al.
Published: (2015-01-01)