Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-α

Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-α

Sustained production of elevated levels of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the central nervous system (CNS) is detrimental and directly contributes to the pathogenesis of neurological diseases such as neuromyelitis optica spectrum disorders or cerebral interferonopathies, r...

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Bibliographic Details
Main Authors: Phillip K. West, Barney Viengkhou, Iain L. Campbell, Markus J. Hofer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
microglia
interleukin-6 (IL-6)
interferon-alpha (IFN-α)
PLX5622
central nervous system
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1036799/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1036799/full

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