A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway

A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway

Multiple myeloma (MM), the seco <styleredit/>nd most common haematological malignancy, is currently incurable because patients often develop multiple drug resistance and experience subsequent relapse of the disease. This study aims to identify a potential therapeutic agent...

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Bibliographic Details
Main Authors: Zhang Bibo, Li Bo, Xie Yongsheng, Chang Shuaikang, Xu Zhijian, Hu Huifang, Chen Gege, Zhang Ting, He Jun, Wu Xiaosong, Zhu Huabin, Lai Weiming, Song Dongliang, Lu Ying, Jia Xinyan, Zhu Weiliang, Shi Jumei
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-02-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
DCZ0358
apoptosis
cell cycle arrest
multiple myeloma
JAK2/STAT3 pathway
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023014

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023014

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