Lipoteichoic Acid Accelerates Bone Healing by Enhancing Osteoblast Differentiation and Inhibiting Osteoclast Activation in a Mouse Model of Femoral Defects

Lipoteichoic Acid Accelerates Bone Healing by Enhancing Osteoblast Differentiation and Inhibiting Osteoclast Activation in a Mouse Model of Femoral Defects

Lipoteichoic acid (LTA) is a cell wall component of Gram-positive bacteria. Limited data suggest that LTA is beneficial for bone regeneration in vitro. Thus, we used a mouse model of femoral defects to explore the effects of LTA on bone healing in vivo. Micro-computed tomography analysis and double-...

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Bibliographic Details
Main Authors: Chih-Chien Hu, Chih-Hsiang Chang, Yi-min Hsiao, Yuhan Chang, Ying-Yu Wu, Steve W. N. Ueng, Mei-Feng Chen
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
lipoteichoic acid
bone healing
femoral defect
fracture
alkaline phosphatase
osteopontin
Online Access:https://www.mdpi.com/1422-0067/21/15/5550

Internet

https://www.mdpi.com/1422-0067/21/15/5550

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