Kv1.3 Blockade Alleviates White Matter Injury through Reshaping M1/M2 Phenotypes via the NF-κB Signaling Pathway after Intracerebral Hemorrhage

Kv1.3 Blockade Alleviates White Matter Injury through Reshaping M1/M2 Phenotypes via the NF-κB Signaling Pathway after Intracerebral Hemorrhage

Background: White matter injury (WMI) in basal ganglia usually induces long-term disability post intracerebral hemorrhage (ICH). Kv1.3 is an ion channel expressed in microglia and induces neuroinflammation after ICH. Here, we investigated the functions and roles of Kv1.3 activation-induced inflammat...

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Bibliographic Details
Main Authors: Bo Wang, Jie Chen, Shuhong Wang, Lin Chen, Xuyang Zhang, Tengyuan Zhou, Jun Zhong, Chao Zhang, Yijia He, Yonglin Zuo, Hua Feng, Yi Yin, Hongfei Ge
Format: Article
Language:English
Published: IMR Press 2023-12-01
Series:Journal of Integrative Neuroscience
Subjects:
intracerebral hemorrhage
kv1.3
microglia
pap-1
neuroinflammation
Online Access:https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206171

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https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206171

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