Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

Abstract Background The receptor-binding domain (RBD) variants of SARS-CoV-2 could impair antibody-mediated neutralization of the virus by host immunity; thus, prospective surveillance of antibody escape mutants and understanding the evolution of RBD are urgently needed. Methods Using the single B c...

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Bibliographic Details
Main Authors: Chunyan Yi, Xiaoyu Sun, Yixiao Lin, Chenjian Gu, Longfei Ding, Xiao Lu, Zhuo Yang, Yaguang Zhang, Liyan Ma, Wangpeng Gu, Aidong Qu, Xu Zhou, Xiuling Li, Jianqing Xu, Zhiyang Ling, Youhua Xie, Hongzhou Lu, Bing Sun
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Genome Medicine
Subjects:
SARS-CoV-2
Neutralizing antibodies
RBD antigenic sits
Escape variants
Online Access:https://doi.org/10.1186/s13073-021-00985-w

Internet

https://doi.org/10.1186/s13073-021-00985-w

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