Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome pathway (ALP) are the two major protein degradation pathways, which are critical for proteostasis. Growing evidence indicates that proteasome inhibition-induced ALP activation is an adaptive response. Transcription Factor EB (TFEB) is a maste...

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Bibliographic Details
Main Authors: Chunyan Li, Xin Wang, Xuezhi Li, Kaixin Qiu, Fengjuan Jiao, Yidan Liu, Qingxia Kong, Yan Liu, Yili Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ubiquitin-proteasome pathway
autophagy-lysosome pathway
TFEB
TFEB nuclear translocation
TFEB dephosphorylation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00170/full

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https://www.frontiersin.org/article/10.3389/fcell.2019.00170/full

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