Parkinson's disease pathology is directly correlated to SIRT3 in human subjects and animal models: Implications for AAV.SIRT3-myc as a disease-modifying therapy

Parkinson's disease pathology is directly correlated to SIRT3 in human subjects and animal models: Implications for AAV.SIRT3-myc as a disease-modifying therapy

In Parkinson's disease (PD), post-mortem studies in affected brain regions have demonstrated a decline in mitochondrial number and function. This combined with many studies in cell and animal models suggest that mitochondrial dysfunction is central to PD pathology. We and others have shown that...

Full description

Bibliographic Details
Main Authors: Dennison Trinh, Ahmad R. Israwi, Harsimar Brar, Jose E.A. Villafuerte, Ruella Laylo, Humaiyra Patel, Sabika Jafri, Lina Al Halabi, Shaumia Sinnathurai, Kiran Reehal, Alyssa Shi, Vayisnavei Gnanamanogaran, Natalie Garabedian, Ivy Pham, Drake Thrasher, Philippe P. Monnier, Laura A. Volpicelli-Daley, Joanne E. Nash
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
α-synuclein pre-formed fibrils
Rat model
Disease-modifying
Sirtuin 3
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123003029

Internet

http://www.sciencedirect.com/science/article/pii/S0969996123003029

Similar Items